Histone Deacetylase 6 Inhibition Exploits Selective Metabolic Vulnerabilities in LKB1 Mutant, KRAS Driven NSCLC
Hua Zhang,Christopher S. Nabel,Dezhi Li,Ruth OConnor, Caroline R. Crosby,Sarah M. Chang,Yuan Hao, Robyn Stanley,Soumyadip Sahu, Daniel S. Levin,Ting Chen,Sittinon Tang,Hsin-Yi Huang,Mary Meynardie,Janaye Stephens,Fiona Sherman,Alison Chafitz,Naoise Costelloe,Daniel A. Rodrigues,Hilda Fogarty,Miranda G. Kiernan,Fiona Cronin,Eleni Papadopoulos, Magdalena Ploszaj,Vajira Weerasekara,Jiehui Deng,Patrick Kiely,Nabeel Bardeesy,Matthew G. Vander Heiden,Triona Ni Chonghaile,Catriona M. Dowling,Kwok-Kin Wong Journal of Thoracic Oncology（2023）
Key words
HDAC6,KRAS,LKB1,Glycolysis,Glutaminase inhibition,Oxidative stress
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