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A Conserved SH3-like Fold in Diverse Putative Proteins Tetramerizes into an Oxidoreductase Providing an Antimicrobial Resistance Phenotype

Claudele Lemay-St-Denis,Lorea Alejaldre,Zakaria Jemouai,Kiana Lafontaine, Maxime St-Aubin, Katia Hitache,Donya Valikhani,Nuwani W. Weerasinghe,Myriam Letourneau,Christopher J. Thibodeaux,Nicolas Doucet,Christian Baron,Janine N. Copp,Joelle N. Pelletier

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES（2023）

Cited 6|Views26
Key words
evolutionary biochemistry,enzyme evolution,R67 DHFR,antibiotic resistance,SH3-like fold
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