横向主动脉缩窄术致兔心力衰竭模型的建立
DOAJ (DOAJ Directory of Open Access Journals)（2022）
Abstract
目的 探讨应用横向主动脉缩窄(transverse aortic constriction,TAC)术建立兔心力衰竭模型的方法及可行性.方法 25只普通级健康雄性日本大耳兔,随机分为手术组(n=15)和假手术组(n=10).手术组动物行TAC术,建立兔心力衰竭模型;假手术组行开胸手术但不进行缩窄操作.术后4周和8周超声检查心脏功能,术后8周检测降主动脉流速;结合分子生物学指标及病理学观察,评估TAC术建立兔心力衰竭模型的可行性和稳定性.结果 TAC术后8周,手术组兔存活13只,假手术组兔存活10只,手术组主动脉弓缩窄处血流速度均大于2.20 m/s.与假手术组比较,手术组心率、升主动脉内径、左房舒张末期内径、左室舒张末期内径和左室收缩末期内径均明显增加(P<0.05),左室射血分数明显降低(P<0.05);与假手术组相比,手术组左心室组织中NT-proBNP和β-MHC含量明显升高(P<0.05).病理切片显示,TAC术后8周,手术组心肌细胞肥大且排列紊乱,心肌纤维束增宽.TAC术后4周,与假手术组相比,手术组左室舒张末期室间隔厚度和左室后壁舒张末期厚度均显著增加(P<0.05).结论 应用TAC术建立实验兔心力衰竭模型是有效且可行的.心脏超声是评估主动脉弓缩窄程度及心力衰竭建模成功与否的有效手段.手术组实验兔在TAC术后8周时心肌出现失代偿反应,形成不可逆的心力衰竭.
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Key words
ultrasound,transverse aortic constriction,heart failure,rabbits
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