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Continuous Process to Safely Manufacture an Aryldiazoacetate and Its Direct Use in a Dirhodium-Catalyzed Enantioselective Cyclopropanation

Stephen P. Lathrop,Laurie B. Mlinar,Onkar N. Manjrekar, Yong Zhou,Kaid C. Harper,Eric R. Sacia, Molly Higgins,Andrew R. Bogdan,Zhe Wang,Steven M. Richter,Wei Gong,Eric A. Voight,Jeremy Henle,Moiz Diwan,Jeffrey M. Kallemeyn,Jack C. Sharland,Bo Wei,Huw M. L. Davies

ORGANIC PROCESS RESEARCH & DEVELOPMENT（2023）

Cited 12|Views24
Key words
flow chemistry,aryldiazoacetate,continuous drying,cyclopropanation,process safety
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