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Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor

Liang Zhang,Daniel J. Griffin,Matthew G. Beaver,Laura E. Blue,Christopher J. Borths,Derek B. Brown,Seb Caille,Ying Chen,Alan H. Cherney,Brian M. Cochran,John T. Colyer,Michael T. Corbett,Tiffany L. Correll,Richard D. Crockett,Xi-Jie Dai,Peter K. Dornan,Robert P. Farrell,Simon J. Hedley,Hsiao-Wu Hsieh,Liang Huang,Seth Huggins,Min Liu,Michael A. Lovette,Kyle Quasdorf,William Powazinik,Jonathan Reifman,Jo Anna Robinson,Rahul P. Sangodkar,Sonika Sharma,Srividya Sharvan Kumar,Austin G. Smith,Gabrielle St-Pierre,Jason S. Tedrow,Oliver R. Thiel, Jonathan V. Truong,Shawn D. Walker,Carolyn S. Wei,Ashraf Wilsily,Yong Xie, Ning Yang,Andrew T. Parsons

ORGANIC PROCESS RESEARCH & DEVELOPMENT（2022）

Cited 17|Views28
Key words
atropisomerism,axial chirality,acrylamide,KRAS,Suzuki-Miyaura,POCl3,chlorination,BOC,palladium,cross-coupling,covalent inhibitor,catalysis
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