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    • 应用二代测序技术对甲状腺乳头状癌突变基因谱及临床特征相关性的研究

    Meng Su, Chen Ping,Yang Zhixue,Wei Jinrong, Chen Nan,Wu Yanlin,Zhao Shengbin,Zhou Sujuan,Jiang Guoqin

    Chinese Journal of Experimental Surgery（2022）

    Cited 0|Views10
    Abstract
    目的 分析甲状腺乳头状癌组织标本的分子特征,探究其基因突变谱与其临床特征的相关性.方法 收集2020年7月至2021年5月于苏州大学附属第二医院手术且病理确认为甲状腺乳头状癌的71例患者(共79份)新鲜肿瘤组织标本,并统计其临床及病理学资料.应用二代测序技术对肿瘤组织标本进行检测,研究其病理性突变基因特征,并使用Fisher精确概率检验方法分析其与临床病理特征之间的相关性.结果 95％的新鲜肿瘤组织标本被检测到不同的病理性突变或融合,15％的新鲜肿瘤组织标本存在至少2种不同的病理性基因共突变或融合;甲状腺乳头状癌患者中,有病理性突变或融合组的中央组淋巴结转移率明显高于无病理性突变或融合组(62.7％比0,P＜0.05).结论 具有病理性基因突变或融合的患者更容易出现中央组淋巴结转移,据此我们认为术前对肿瘤组织进行二代测序分析其分子特征有利于准确判断中央组淋巴结转移情况、方便制定精准的手术方案.
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    Key words
    Breast cancer,Insulin-like growth factor binding protein-6,Proliferation cell nuclear antigen,Pathology
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