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超声联合免疫组织化学指标预测新辅助化疗后乳腺癌转移性腋窝淋巴结病理完全缓解

Chinese Journal of Medical Imaging Technology(2022)

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Abstract
目的 观察超声联合免疫组织化学指标预测新辅助化疗(NACT)后乳腺癌转移性腋窝淋巴结病理完全缓解(pCR)的价值.方法 纳入155例接受NACT的乳腺癌伴腋窝淋巴结转移患者,根据腋窝淋巴结清扫(ALND)术后病理结果将其分为pCR组(n=59)及非pCR组(n=96);比较2组NACT前免疫组织化学指标及乳腺癌病灶及腋窝淋巴结的超声特征,建立logistic预测模型,观察其预测NACT后腋窝淋巴结pCR的价值.结果 2组乳腺癌原发灶Ki-67表达、人表皮生长因子受体2(HER-2)表达及腋窝转移性淋巴结短径、最大皮质厚度和形态差异均有统计学意义(P均<0.05).logistic预测模型预测NACT后乳腺癌腋窝转移性淋巴结pCR的AUC为0.734,敏感度为42.37%(25/59),特异度为84.38%(81/96).结论 NACT前超声联合免疫组织化学预测NACT后乳腺癌转移性腋窝淋巴结pCR具有一定价值.
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