Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease

Stefano Fiorucci,Pasquale Rapacciuolo,Bianca Fiorillo,Rosalinda Roselli,Silvia Marchiano,Cristina Di Giorgio,Martina Bordoni,Rachele Bellini,Chiara Cassiano,Paolo Conflitti,Bruno Catalanotti,Vittorio Limongelli,Valentina Sepe,Michele Biagioli,Angela Zampella

Frontiers in Pharmacology（2022）

Cited 5|Views5

Key words

cysteinyl-leukotriene-receptor 1,g-protein coupled bile acid receptor 1,nonalcoholic fatty liver disease,nonalcoholic steatohepatitis (NASH),liver inflammation,REV5901 derivatives

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