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    • Expression of MMP-9 after Cerebral Ischemic Reperfusion and the Effects of Artificial Synthetic E-selectin in Rats

    Xiao Liu

    openalex

    First Affiliated Hospital of Soochow University

    Cited 1|Views2
    Abstract
    Aim:To study the mechanisms of tumor necrosis factor-αand matrix metalloproteinases-9 in rat brain suffured with ischemia reperfusion injury and further explore the protective mechanism of artificial synthetic E-selectin in cerebral ischemia reperfusion injury model of rats.Methods:Healthy Sprague-Dawley rats were randomly divided into operation group,sham-operation group,artificial synthetic E-selectin treated group.The cerebral ischemia reperfusion injury model was established by inserting thread into middle cerebral artery.The treated group was established by the same method with operation group after the artificial synthetic E-selectin was injected into the femoral vein preoperation.The contents of TNF-αand MMP-9 expression in rat brain were measured by immunohistochemical methods,and MMP-9 mRNA was detected by reverse transcription PCR.Results:The expression of TNF-α,MMP-9 and MMP-9 mRNA in operation group were more than sham-operation group(P0.05);the expression of TNF-α,MMP-9 and MMP-9 mRNA in treated group were less than operation group(P0.05).Statistical results showed that the expression of MMP-9 mRNA was correlated with TNF-αand MMP-9 respectively.Conclusion:TNF-αinduces MMP-9 expression at transcriptional level in rats suffered with cerebral ischemia reperfusion injury.The protection mechanism of artificial synthetic E-selectin for cerebral ischemia reperfusion injury is probably that it inhibits the synthesis of MMP-9 mRNA which is induced by TNF-αat the transcriptional level,resulting in the decrease of MMP-9 expression.
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