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首发精神分裂症治疗前后甲状腺相关激素水平变化的研究

China Modern Doctor(2021)

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Abstract
目的 观察首发精神分裂症治疗前后甲状腺相关激素水平变化.方法 选取109例首发精神分裂症患者(观察组)和113名健康体检者(对照组)作为研究对象.观察在接受抗精神病药物治疗前、接受药物治疗后1个月及第12月、18月的甲状腺相关激素水平.依据患者出院后有无连续服药,将观察组分为服药组(55例)和未服药组(54例),比较两组治疗前后的甲状腺相关激素水平.结果 一般资料比较:观察组、对照组性别构成,年龄,差异无统计学意义(P>0.05).治疗前,观察组FT3、TT4、TSH水平高于对照组;治疗后,观察组FT4、TT3水平低于对照组;观察组治疗前后对照,FT3、TT4、TT3、TT4较前下降,差异均有统计学意义(P<0.05).未服药组治疗前和12月时FT3、FT4、TT3、TT4、TSH水平比较,差异均无统计学意义(P>0.05).服药组18月时FT4、TT3、TT4均低于治疗前水平;未服药组18月时仅FT4、TT4低于治疗前水平,差异有统计学意义(P<0.05).结论 精神分裂症患者的FT3、TT4、TSH水平较正常人增高;FT3、TT4水平降低是疾病好转的信号;连续服用抗精神病药物会使患者的FT3、FT4、TT3、TT4水平下降;中断服药,甲状腺相关激素会恢复至未服药水平.
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