First-Generation Asymmetric Synthesis of the Selective Estrogen Receptor Degrader GDC-9545 (giredestrant) Featuring a Highly Efficient Pictet–Spengler Reaction and a C–N Coupling Reaction
ORGANIC PROCESS RESEARCH & DEVELOPMENT（2022）
关键词
Pictet-Spengler reaction,Buchwald-Hartivig C-N coupling,selective estrogen receptor degrader,SERD
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