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Elevated Enhancer-Oncogene Contacts and Higher Oncogene Expression Levels by Recurrent CTCF Inactivating Mutations in Acute T Cell Leukemia

Willem K. Smits,Carlo Vermeulen,Rico Hagelaar,Shunsuke Kimura,Eric M. Vroegindeweij,Jessica G. C. A. M. Buijs-Gladdines,Ellen van de Geer,Marjon J. A. M. Verstegen,Erik Splinter,Simon V. van Reijmersdal,Arjan Buijs,Niels Galjart, Winfried van Eyndhoven,Max van Min,Roland Kuiper,Patrick Kemmeren,Charles G. Mullighan,Wouter de Laat,Jules P. P. Meijerink

Cell Reports（2023）

引用 3|浏览42
关键词
T cell acute lymphoblastic leukemia,TLX3,BCL11B,CTCF mutation,competitive chromatin looping,enhancer insulation,oncogene regulation
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