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Development and Scale-Up of an Asymmetric Synthesis of AZD8186 Using the Fukuyama Modification of the Mitsunobu Reaction

Peter R. Moore,James C. Muir,Jerome Dubiez,Kevin W. Leslie,Paula Tomlin,Marc Mccormick,Sophie L. Janbon,Philip Cornwall,Per Ryberg, Robert Berg

Organic Process Research & Development（2021）

Cited 6|Views11
Key words
asymmetric synthesis,Mitsunobu reaction,Fukuyama modification,transfer hydrogenation,Heck reaction,pi3kβ inhibitor
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