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Discovery of a First-in-class Reversible DNMT1-selective Inhibitor with Improved Tolerability and Efficacy in Acute Myeloid Leukemia.

Melissa B. Pappalardi,Kathryn Keenan,Mark Cockerill,Wendy A. Kellner,Alexandra Stowell,Christian Sherk,Kristen Wong,Sarath Pathuri,Jacques Briand,Michael Steidel,Philip Chapman,Arthur Groy,Ashley K. Wiseman,Charles F. McHugh,Nino Campobasso,Alan P. Graves,Emma Fairweather,Thilo Werner,Ali Raoof,Roger J. Butlin,Lourdes Rueda,John R. Horton,David T. Fosbenner,Cunyu Zhang,Jessica L. Handler,Morris Muliaditan,Makda Mebrahtu,Jon-Paul Jaworski,Dean E. McNulty,Charlotte Burt,H. Christian Eberl,Amy N. Taylor,Thau Ho, Susan Merrihew,Shawn W. Foley,Anna Rutkowska,Mei Li,Stuart P. Romeril,Kristin Goldberg,Xing Zhang,Christopher S. Kershaw,Marcus Bantscheff,Anthony J. Jurewicz,Elisabeth Minthorn,Paola Grandi,Mehul Patel,Andrew B. Benowitz,Helai P. Mohammad,Aidan G. Gilmartin,Rab K. Prinjha,Donald Ogilvie,Christopher Carpenter,Dirk Heerding,Stephen B. Baylin,Peter A. Jones,Xiaodong Cheng,Bryan W. King,Juan I. Luengo,Allan M. Jordan,Ian Waddell,Ryan G. Kruger,Michael T. McCabe

Nature cancer（2021）

Cited 128|Views55
Key words
Cancer therapy,Drug discovery,Haematological cancer,Life Sciences,general
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