WeChat Mini Program
Old Version Features

Optimization of Physicochemical Properties of Pyridone-Based EP3 Receptor Antagonists

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS(2021)

Janssen Res & Dev LLC

Cited 4|Views12
Abstract
A novel series of pyridone-based EP3 receptor antagonists was optimized for good physical properties and oral bioavailability in rodents. The lead compounds 3h, 3l and 4d displayed good in vitro profiles, moderate to good metabolic stability and good rodent PK profiles with low clearance, high oral exposure and acceptable half-life.
More
Translated text
Key words
EP3,PGE2,Pyridone,Metabolic stability
PDF
Bibtex
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn
Chat Paper
Summary is being generated by the instructions you defined