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Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis.

Qingjie Liu,Hai-Yun Xiao,Douglas G. Batt,Zili Xiao,Yeheng Zhu,Michael G. Yang, Ning Li,Shiuhang Yip,Peng Li,Dawn Sun,Dauh-Rurng Wu,Max Ruzanov,John S. Sack,Carolyn A. Weigelt,Jinhong Wang,Sha Li,David J. Shuster,Jenny H. Xie,Yunling Song,Tara Sherry,Mary T. Obermeier,Aberra Fura,Kevin Stefanski,Georgia Cornelius,Silvi Chacko,Purnima Khandelwal,Shailesh Dudhgaonkar,Anjuman Rudra,Jignesh Nagar,Venkata Murali,Arun Govindarajan,Rex Denton,Qihong Zhao,Nicholas A. Meanwell,Robert Borzilleri,T. G. Murali Dhar

ACS Medicinal Chemistry Letters（2021）

Cited 4|Views51
Key words
ROR gamma t,RORc,inverse agonist,aza substitution,acanthosis,collagen-induced arthritis
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