皮下特异性免疫治疗两种注射部位比较
Chinese Journal of Allergy & Clinical Immunology（2019）
Abstract
目的 评估皮下特异性免疫治疗中,两种注射部位的疼痛评分和不良反应发生情况.方法 采用自身、 交叉对照研究,将在本中心接受屋尘螨变应原制剂(Alutard?)皮下免疫治疗的60例患者分为2组,A组30例患者先在上臂三角肌下缘接受7次过敏原皮下注射,然后在上臂远端1/3外侧接受7次过敏原皮下注射;B组30例患者先在上臂远端1/3外侧接受7次过敏原皮下注射,然后在上臂三角肌下缘接受7次过敏原皮下注射.运用疼痛视觉模拟评估(VAS)量表评估每次注射时的疼痛情况,并记录不良反应发生情况.结果 60例患者在上臂三角肌下缘注射时的VAS评分(1.79±0.93)低于上臂远端1/3外侧(2.76±1.23),差异有统计学意义(P<0.05).患者在上臂三角肌下缘和上臂远端1/3外侧接受治疗的局部不良反应发生率分别为5.47％和6.42％,差异无统计学意义(P>0.05).结论 两种注射部位患者的疼痛程度均为轻度,选择上臂三角肌下缘患者的疼痛感觉较上臂远端1/3外侧注射时轻,但不良反应发生率无差异,故推荐上臂三角肌下缘作为皮下特异性免疫治疗的首选注射部位.
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