BALB/c小鼠经不同途径感染单纯疱疹病毒Ⅱ型的病理学比较分析
Laboratory Animal and Comparative Medicine（2020）
Abstract
目的 比较BALB/c小鼠经不同途径感染单纯疱疹病毒Ⅱ型(HSV-2)后的病理学变化.方法 分别采用经阴道、鼻腔和眼角膜3种不同的攻毒方式使BALB/c小鼠感染HSV-2,观察小鼠的临床表现及攻毒部位和神经组织的病理变化,检测神经组织中的病毒载量.结果 鼻腔组小鼠无明显症状,但至观察期结束仅有27.27％的存活率;阴道组小鼠表现不同程度的外阴炎以及体质量下降等症状,观察至感染后8d,小鼠的存活率已为0;角膜组小鼠表现不同程度的角膜炎,观察期结束存活率仍有63.64％.病理变化结果显示,鼻腔组小鼠仅脑组织存在明显的病理变化;阴道组和角膜组小鼠攻毒部位均发生明显的病理变化,但阴道组小鼠脑和脊髓均可见明显的病理变化.神经组织病毒载量检测结果表明,与对照组相比,3个实验组小鼠脑和脊髓中HSV-2的病毒载量均显著升高,且随着感染时间的增加而升高.结论 BALB/c小鼠经3种不同途径感染HSV-2均可引起小鼠不同程度的病理学变化.本研究为HSV-2感染引发的神经系统疾病的发病机制研究提供了理论基础.
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