脾酪氨酸激酶抑制剂治疗慢性淋巴细胞白血病的机制与现状
Clinical Focus(2018)
Abstract
慢性淋巴细胞白血病(CLL)是一种以单克隆B淋巴细胞增殖为特征,尚不能彻底治愈的血液系统肿瘤.一些新型小分子药物的出现为复发/难治的CLL患者提供了新的治疗策略,包括布鲁顿酪氨酸激酶(BTK)抑制剂、磷脂酰肌醇3-激酶(phosphoinositide 3-kinase delta,PI3K)抑制剂、脾酪氨酸激酶(Syk)抑制剂等.本文就Syk抑制剂在CLL中的作用机制及近年来的研究进展进行综述.
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