315例吡嗪酰胺血药浓度监测结果分析
Journal of Clinical Pulmonary Medicine（2015）
Abstract
目的：分析吡嗪酰胺血药浓度监测结果,指导临床合理用药。方法采用回顾性分析的方法,收集我院2013年9月至2014年10月315例肺结核住院患者吡嗪酰胺的血药浓度检测结果,采用 SPSS 18．0软件进行统计学分析,计量资料采用 t 检验,计数资料采用χ2检验,以 P <0．05为差异有统计学意义。结果(1)315例结核病患者中,低于正常浓度11．7%(37/315),正常浓度46．7%(147/315),高于正常浓度45．2%(131/315)(2)男性血药浓度及每千克体质量剂量分别为(17．54±5．80)mg/ L、(24．99±3．17)mg/ kg,明显低于女性[分别为(23．38±8．22) mg/ L、(29．03±4．50) mg/ kg],差异有统计学意义(t 值分别为-6．586、-8．002,P 值分别为0．000、0．000)(3)不同年龄段患者的血药浓度无统计学差异(F =1．237,P =0．296)。结论加强血药浓度监测,实现合理用药。
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Key words
pyrazinamide,plasma concentration,tuberculosis
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