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    • 染色体重塑分子SNF5血清差异性表达用于早期诊断乳腺癌的初步研究

    华科俊,胡贤杰, 周关琪,张星,陈文忠,王辉,赵亲明

    Chinese Journal of General Practice（2017）

    Cited 0|Views3
    Abstract
    目的 探究染色体重塑分子SNF5血清差异性表达用于早期诊断乳腺癌的可行性.方法 选择2010年8月-2015年8月间于宁波大学医学院附属鄞州人民医院病理检查证实的196例乳腺癌患者(0期23例、Ⅰ期46例、Ⅱ期29例、Ⅲ期67例、Ⅳ期31例,平均年龄36.3岁)为研究对象,并选择同期在该院健康体检的64名志愿者(平均年龄37.9岁)为对照组.采用实时定量PCR检测2组外周血血清中SNF5的表达水平.采用统计学软件对2组SNF5水平进行统计学分析,并采用ROC曲线分析SNF5诊断乳腺癌的价值,进而探究染色体重塑分子SNF5血清差异性表达用于早期诊断乳腺癌的可行性.结果 乳腺癌患者外周血血清中SNF5水平显著性高于对照组(P＜0.05),0、Ⅰ、Ⅱ、Ⅲ、Ⅳ期乳腺癌患者SNF5水平分别是对照组的13、15、15、16、23倍(均P＜0.05).ROC曲线结果显示,SNF5诊断乳腺癌的敏感度与特异度分别为82％和93％,曲线下面积为0.8734(95％ CI:0.923～ 0.944).结论 染色体重塑分子SNF5在乳腺癌患者中的表达明显升高,其可作为早期诊断乳腺癌肿瘤的生物标志物,具有敏感度、特异度高的优点.
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