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AFP、PIVKA-Ⅱ联合检测对原发性肝癌的诊断价值

Hainan Medical Journal(2020)

Cited 3|Views16
Abstract
目的 探讨血清甲胎蛋白(AFP)、异常凝血酶原(PIVKA-Ⅱ)联合检测对原发性肝癌的诊断价值,为患者的临床诊治提供指导.方法 选择2019年5~11月在南方医科大学深圳医院就诊的56例原发性肝癌患者作为观察组,选择我院同期体检健康人群50例作为对照组.检测并比较两组受检者的血清AFP、PIVKA-Ⅱ水平,采用受试者工作特征(ROC)曲线分析AFP、PIVKA-Ⅱ对原发性肝癌诊断的敏感度、特异度及准确度.结果 观察组患者的血清AFP、PIVKA-Ⅱ水平分别为(132.63±17.24)ng/mL、(1562.56±129.32)mAU/mL,明显高于对照组的(2.35±0.78)ng/mL、(20.08±2.13)mAU/mL,差异均有显著统计学意义(P<0.01);AFP诊断原发性肝癌的ROC曲线下面积为0.805,95%CI为0.723~0.888,PIVKA-Ⅱ诊断原发性肝癌的ROC曲线下面积为0.678,95%CI为0.577~0.779,AFP+PIVKA-Ⅱ诊断原发性肝癌的ROC曲线下面积为0.914,95%CI为0.890~0.939,AFP、PIVKA-Ⅱ单独检测分别和联合检测曲线下面积比较差异均有统计学意义(P<0.05);AFP+PIVKA-Ⅱ联合检测的敏感度、特异度及准确度为96.43%、92.86%及94.64%,均明显高于AFP的82.14%、76.79%、79.62%和PIVKA-Ⅱ的82.14%、75.00%、77.68%,差异均有统计学意义(P<0.05).结论 AFP、PIVKA-Ⅱ对原发性肝癌均具有较高的诊断阳性率,且两者联合检测可提高原发性肝癌的诊断价值.
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