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Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrim idin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Qibin Su,Erica Banks,Geraldine Bebernitz,Kirsten Bell, Cassandra F. Borenstein,Huawei Chen, Claudio E. Chuaqui,Nanhua Deng,Andrew D. Ferguson,Sameer Kawatkar,Neil P. Grimster,Linette Ruston,Paul D. Lyne,Jon A. Read, Xianyou Peng,Xiaohui Pei,Stephen Fawell, Zhanlei Tang,Scott Throner,Melissa M. Vasbinder,Haoyu Wang,Jon Winter-Holt,Richard Woessner,Allan Wu,Wenzhan Yang,Michael Zinda,Jason G. Kettle

JOURNAL OF MEDICINAL CHEMISTRY（2020）

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