Optimization of a Series of Potent, Selective and Orally Bioavailable SYK Inhibitors.
Neil P. Grimster,Lakshmaiah Gingipalli,Bernard Barlaam,Qibin Su,XiaoLan Zheng,David Watson,Haixia Wang,Iain Simpson,Andy Pike,Amber Balazs,Scott Boiko,Timothy P. Ikeda,Anna C. Impastato,Natalie H. Jones,Sameer Kawatkar,Paul Kemmitt,Scott Lamont,Joe Patel,Jon Read,Ujjal Sarkar,Li Sha,Ronald C. Tomlinson,Haiyun Wang,David M. Wilson, Troy E. Zehnder,Lianghe Wang,Peng Wang,Frederick W. Goldberg,Wenlin Shao,Stephen Fawell,Hannah Dry,James E. Dowling,Scott D. Edmondson Bioorganic & Medicinal Chemistry Letters（2020）
Key words
SYK,Bioavailable,Small molecule
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