Optimization of Nicotinamides As Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis.
Satheesh Nair,Sreekantha Ratna Kumar,Venkatram Reddy Paidi,Ramesh Sistla, Durgarao Kantheti,Subba Rao Polimera, Soodamani Thangavel, Amrita Jha Mukherjee,Mitalee Das,Rajeev S. Bhide,William J. Pitts,Natesan Murugesan, Shailesh Dudhgoankar,Jignesh Nagar,Siva Subramani, Debarati Mazumder,Julie A. Carman,Deborah A. Holloway,Xin Li,Mark P. Fereshteh,Stefan Ruepp,Kamalavenkatesh Palanisamy,T. Thanga Mariappan,Srinivas Maddi,Ajay Saxena,Paul Elzinga,Anjaneya Chimalakonda,Qian Ruan,Kaushik Ghosh, Sucharita Bose,John Sack,Chunhong Yan,Susan E. Kiefer,Dianlin Xie,John A. Newitt,S. Pon Saravanakumar,Richard A. Rampulla,Joel C. Barrish,Percy H. Carter,John Hynes ACS Medicinal Chemistry Letters（2020）
Key words
IRAK4,kinase,lupus,TLR,psoriasis
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