Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species
Wu Yang,Yufeng Wang,Amy Lai,Charles G. Clark,James R. Corte,Tianan Fang,Paul J. Gilligan,Yoon Jeon,Kumar B. Pabbisetty,Richard A. Rampulla,Arvind Mathur,Mahammed Kaspady, Premsai Rai Neithnadka, Arunachalam Arumugam, Sivashankaran Raju,Karen A. Rossi,Joseph E. Myers,Steven Sheriff,Zhen Lou,Joanna J. Zheng,Silvi A. Chacko,Jeffrey M. Bozarth,Yiming Wu,Earl J. Crain,Pancras C. Wong,Dietmar A. Seiffert,Joseph M. Luettgen,Patrick Y. S. Lam,Ruth R. Wexler,William R. Ewing Journal of medicinal chemistry（2020）
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