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Continuous Process Improvement in the Manufacture of Carfilzomib, Part 2: an Improved Process for Synthesis of the Epoxyketone Warhead

Matthew G. Beaver,Xianqing Shi,Jan Riedel, Parth Patel,Alicia Zeng,Michael T. Corbett,Jo Anna Robinson,Andrew T. Parsons,Sheng Cui,Kyle Baucom,Michael A. Lovette,Elcin Icten,Derek B. Brown,Ayman Allian,Tawnya G. Flick, Wendy Chen, Ning Yang,Shawn D. Walker

Organic Process Research & Development（2020）

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关键词
asymmetric epoxidation,continuous manufacturing,carfilzomib
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