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Design and Optimization of a Series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual Inhibitors of TYK2 and JAK1.

Andrew Fensome,Catherine M. Ambler,Eric Arnold,Mary Ellen Banker,James D. Clark,Martin E. Dowty,Ivan Efremov,Andrew Flick,Brian S. Gerstenberger, Roger S. Gifford,Ariamala Gopalsamy,Martin Hegen,Jason Jussif,David C. Limburg,Tsung H. Lin,Betsy S. Pierce,Raman Sharma,John Trujillo,Felix F. Vajdos,Fabien Vincent,Zhao-Kui Wan,Li Xing,Xiaojing Yang,Xin Yang

Bioorganic & Medicinal Chemistry（2020）

Cited 12|Views48
Key words
TYK2,JAK1,Kinase,Autoimmune,Inflammation,Psoriasis,Arthritis
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