Estimation of Fraction Dissolved after Intratracheal Delivery of a Potent Janus Kinase Inhibitor, Ijak-001, with Low Solubility in Rat and Sheep: Impact of Preclinical PKPD on Inhaled Human Dose Projection.
Journal of Aerosol Medicine and Pulmonary Drug Delivery(2019)
关键词
asthma,eosinophil,fraction absorbed,JAK inhibitor,preclinical PKPD,tofacitinib,topical inhalation delivery
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