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ORP4L Extracts and Presents PIP2 from Plasma Membrane for PLCβ3 Catalysis: Targeting It Eradicates Leukemia Stem Cells.

Wenbin Zhong,Mengyang Xu,Chanjuan Li,Biying Zhu,Xiuye Cao,Dan Li,Huanzhao Chen,Chunxiu Hu,Rong Li,Chengwei Luo,Guoping Pan,Wenqiang Zhang,Chaofeng Lai,Tong Wang,Xin Du,Hong Chen,Guowang Xu,Vesa M. Olkkonen,Pingsheng Lei,Jun Xu,Daoguang Yan

Cell Reports（2019）

Cited 39|Views30
Key words
leukemia stem cell,OSBP-related protein 4L,PIP2 hydrolysis,Ca2+ signaling,energy metabolism,therapy
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