Evolution of a Comprehensive, Orthogonal Approach to Sequence Variant Analysis for Biotherapeutics

T. Jennifer Lin,Kathryn M. Beal,Paul W. Brown, Heather S. DeGruttola,Mellisa Ly,Wenge Wang, Chia H. Chu,Robert L. Dufield,Gerald F. Casperson,James A. Carroll,Olga V. Friese,Bruno Figueroa,Lisa A. Marzilli,Karin Anderson,Jason C. Rouse

MAbs（2018）

Cited 22|Views38

Key words

Amino acid analysis,clone selection,mammalian cell line,mammalian cell culture,misincorporation,next generation sequencing,product quality attribute,protein mass spectrometry,sequence variant,therapeutic protein

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