Potent Α-Synuclein Aggregation Inhibitors, Identified by High-Throughput Screening, Mainly Target the Monomeric State.

Martin Kurnik,Cagla Sahin,Camilla Bertel Andersen,Nikolai Lorenzen,Lise Giehm,Hossein Mohammad-Beigi,Christian Moestrup Jessen,Jan Skov Pedersen,Gunna Christiansen,Steen Vang Petersen,Roland Staal,Girija Krishnamurthy,Keith Pitts,Peter H. Reinhart,Frans A. A. Mulder,Scot Mente,Warren D. Hirst,Daniel E. Otzen

Cell chemical biology（2018）

引用 64|浏览49

关键词

high-throughput screen,α-synuclein,Parkinson's disease,aggregation inhibitors,oligomerization,membrane permeabilization,biophysical analysis,αSO formation,amyloid

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