Dependence on the Pyrimidine Biosynthetic Enzyme DHODH is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers
Malvika Koundinya, Judith Sudhalter,Albane Courjaud, Bruno Lionne, Gaetan Touyer,Luc Bonnet,Isabelle Menguy, Isabelle Schreiber,Christelle Perrault,Stephanie Vougier, Brigitte Benhamou,Bailin Zhang,Timothy He,Qiang Gao,Patricia Gee,Daniel Simard,M. Paola Castaldi,Ronald Tomlinson,Stephan Reiling,Matthieu Barrague,Richard Newcombe,Hui Cao,Yanjun Wang,Fangxian Sun,Joshua Murtie,Mark Munson, Eric Yang,David Harper,Monsif Bouaboula,Jack Pollard,Claudine Grepin,Carlos Garcia-Echeverria,Hong Cheng,Francisco Adrian,Christopher Winter, Stuart Licht,Ivan Cornella-Taracido,Rosalia Arrebola,Aaron Morris Cell chemical biology（2018）
Key words
KRAS mutation,synthetic lethality,chemoproteomics,cancer metabolism,pyrimidine biosynthesis
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