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The Structural Determinants of the Bitopic Binding Mode of a Negative Allosteric Modulator of the Dopamine D2 Receptor

Christopher J. Draper-Joyce,Mayako Michino,Ravi Kumar Verma,Carmen Klein Herenbrink,Jeremy Shonberg,Anitha Kopinathan,Peter J. Scammells,Ben Capuano,David M. Thal,Jonathan A. Javitch,Arthur Christopoulos,Lei Shi,J. Robert Lane

Biochemical Pharmacology（2018）

引用 29|浏览8
关键词
G protein-coupled receptor,Dopamine receptor,Allosteric modulation,Bitopic ligands,Molecular dynamics simulations,Mutagenesis
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