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Macrocyclic Inhibitors of Factor XIa: Discovery of Alkyl-Substituted Macrocyclic Amide Linkers with Improved Potency.

James R. Corte,Wu Yang,Tianan Fang,Yufeng Wang,Honey Osuna,Amy Lai,William R. Ewing,Karen A. Rossi,Joseph E. Myers,Steven Sheriff,Zhen Lou,Joanna J. Zheng,Timothy W. Harper,Jeffrey M. Bozarth,Yiming Wu,Joseph M. Luettgen,Dietmar A. Seiffert,Mimi L. Quan,Ruth R. Wexler,Patrick Y. S. Lam

Bioorganic & Medicinal Chemistry Letters（2017）

引用 16|浏览42
关键词
Factor Xla inhibitors,FXla,Activated partial thromboplastin time,aPTT,Thrombosis
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