Structure–Activity Relationships and Discovery of a G Protein Biased Μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9r)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain