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Discovery and SAR of PF-4693627, a Potent, Selective and Orally Bioavailable Mpges-1 Inhibitor for the Potential Treatment of Inflammation

Graciela B. Arhancet,Daniel P. Walker,Sue Metz,Yvette M. Fobian,Steven E. Heasley,Jeffrey S. Carter,John R. Springer,Darin E. Jones,Michael J. Hayes,Alexander F. Shaffer,Gina M. Jerome,Michael T. Baratta,Ben Zweifel,William M. Moore,Jaime L. Masferrer,Michael L. Vazquez

Bioorganic & Medicinal Chemistry Letters（2013）

Cited 52|Views31

Key words

Inflammation,m-PGES-1,Benzoxazole,Clinical candidate,PF-4693627

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