Impact of Input Parameters on the Prediction of Hepatic Plasma Clearance Using the Well-Stirred Model.
Current Drug Metabolism（2010）
Key words
In vivo hepatic clearance prediction,well-stirred model,in vitro in vivo extrapolation (IVIVE),plasma protein binding,microsomal binding or hepatocyte binding or fu(m),blood to plasma ratio (C(B)/C(P)),rat hepatic blood flow
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