Research in the Yang Zhang Lab
Developed accurate and fast physical energy function for de novo protein design (The EvoEF series)
Extended the EvoDesign protocol from monomer design to protein‐protein interaction (PPI) design
Involved in completely redesign of BIR3 domain of the X-linked Inhibitor of Apoptosis Protein (XIAP) to change the apoptosis pathway
Developed SSIPe for accurate binding affinity change prediction upon mutations at protein-protein interface
Assessed the impact of rotamer libraries on protein side-chain modeling using EvoEF2 and simulated annealing optimization
Developing a fast, accurate and deterministic method for side-chain packing (FASPR)
Optimizing the scoring function, searching engine and computational efficiency of EvoDesign
De novo design of peptide inhibitors to block the association of SARS-CoV-2 Spike and human ACE2
Designing Nanobody-based biosensors to detect toxic Aflatoxin B1: a study on protein-ligand interaction design