Theranostic nanoparticles for radiosensitization and medical imaging. Novel treatment technique for ocular disease radiotherapy. Radio-neuromodulation using focused kV x-rays. Use artificial intelligence in image and biological guided radiotherapy and medical image analysis (PET, x-ray, and CT images). Ultrasound parametric imaging.

Tumor-targeted delivery and cell internalization of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy
The goal of this research is to develop gadolinium nanoparticles linked to pH-Low Insertion Peptides as a novel means for simultaneously imaging and radiosensitizing solid tumors and to develop a novel mechanistic biophysical model to predict radiosensitization by nanoparticles. Conjugation of pHLIP to gadolinium nanoparticles actively targets solid tumors’ acidic microenvironment and also delivers cell-impermeable, radiation sensitizing nanoparticles into cancer cells, which is critical for the nanoparticle-induced short-range Auger and photoelectrons to reach the vital cellular targets. The magnetic resonance imaging property of gadolinium can be used to examine in vivo nanoparticle distributions and facilitate enhanced quantitative treatment planning for radiation therapy.