Dr. Seshan’s research interests are in the area of methods for the analysis of high throughput data, specifically from genomic profiling such as DNA sequencing and copy number and methylation arrays. He developed with Dr. Adam Olshen (University of California, San Francisco) the CBS algorithm for the analysis of DNA copy number data and has extended the method to allele copy number estimation. He is collaborating with Drs. Colin Begg, Adam Olshen and Irina Ostrovnaya on extending these methods to distinguish second cancers from metastases. He published, in collaboration with Dr. Ronglai Shen, the FACETS algorithm to estimate allele specific copy numbers and tumor cell fraction using sequencing data. This algorithm is being adopted for use in the DNA sequencing analysis pipeline within and outside MSK. He is responsible for the research computing environment of the Department.