Prof. Bajic is a colossal figure in the field with a rare mix of intelligence, diligence, and kindness. He had broad interests in bioinformatics-related topics and his passion was in facilitating biomedical discoveries by using computational systems, such as data- and text-mining, artificial intelligence, and machine learning for the discovery of mechanisms of gene expression regulation, drug repositioning, biomarker screening, and disease diagnostics. Across various related fields, he had an extensive network of collaborators around the globe and authored more than 400 research publications, edited book chapters, more than 100 software products, invention disclosures, and patents. His work in modeling and artificial intelligence has resulted in several promoter recognition tools and knowledge discovery platforms, and some of them were commercialized. Significantly, he had supported a large number of young colleagues and scientists and over 50 Master’s and doctoral students had graduated under his direct supervision. While fighting with lymphatic cancer in 2019, he still worked actively with his students, conducted scientific discussions with his colleagues, and handled manuscripts for GPB. His spirit and legacy will be respected and carried on by his colleagues and friends, and certainly the next generation of bioinformaticians and computational biologists.