I lead a translational genomics program with the goals of 1) linking cancer genome alterations to clinical outcome; 2) monitoring shifts in cancer and immune cell populations during treatment; and 3) enabling comprehensive genomics as a routine medical test. To achieve these goals, we profile tumours and blood using cell-free DNA, immune repertoire, single-cell and whole-genome sequencing. We also develop software to share these data around the world. Our work advances the knowledgebase and infrastructure necessary to deliver genomic medicine to cancer patients worldwide.