Dr Thomas’s research is focused around the role of the cytoskeleton in the formation and function of platelets and megakaryocytes.

A major aim of his research has been to apply advanced fluorescence microscopy methods to the study of this cells. This includes super-resolution (dSTORM, SIM, SRRF and Expansion Microscopy) and light-sheet fluorescence microscopy (diSPIM). His current research is focusing on a number of areas incuding

How the actin cytoskeleton is organised within single platelets in platelet aggregates and how this underlies proper thrombus formation and stability.
How the actin cytoskeleton regulates the formation of the invaginated membrane system in maturing megakaryocytes, and the role this plays in proper platelet formation and release.
The organisation of the cortical actin cytoskeleton at the plasma membrane and how this is involved in regulating receptor signalling (with a focus on Adenosine A2 receptors).