My research is focused on understanding the structure and function of cytokine receptors and their associated proteins, JAKs (Janus kinases) in normal blood formation and in disease. We aim to elucidate the molecular basis of blood cancers, especially chronic myeloproliferative neoplasms (MPNs) such as Polycythaemia Vera, Essential Thrombocythemia and Myelofibrosis, as well as secondary acute myeloid leukaemia that derive from their progression.