Simon Y. W. Ho mainly focuses on Evolutionary biology, Phylogenetic tree, Molecular clock, Ecology and Ancient DNA. In his research, Mutation is intimately related to Mutation rate, which falls under the overarching field of Evolutionary biology. He has researched Phylogenetic tree in several fields, including Zoology and Phylogenetics. His Phylogenetics study incorporates themes from Algorithm, Genome and Saturation. His studies deal with areas such as Molecular evolution, Statistics, Divergence, Markov chain and Bayes' theorem as well as Molecular clock. His Ecology research integrates issues from Megafauna, Phylogeography, Adaptive radiation and Monte Carlo method.