Shovamayee Maharana

Cellular microenvironment is compartmentalized into biomolecular condensates of RNA binding proteins and RNA. These condensates are dynamic and are formed by a physicochemical process known as liquid-liquid phase separation. Importantly, changes in phase behavior of condensates are associated with pathology in many neurodegenerative disorders. We focus on understanding the role of RNA interactions in formation, phase transition and function of biomolecular condensates.