My research combines epidemiology and randomised clinical trials incorporating high-throughput genomics and metabolomics in the dissection of cardiovascular traits and drug response. As a principal investigator in the MRC Stratified Medicine consortium on Hypertension (AIM HY), I lead the work strand that aims to discover ancestry and metabolomic markers of antihypertensive drug response in large randomised clinical trials. I co-lead the research on the functional dissection and translation of our GWAS discovered hypertension gene, uromodulin, and this involves salt interventional studies, a range of omics studies and a genotype directed clinical trial. I am a member of Generation Scotland executive, section editor of Physiological Genomics and Cardiovascular Risk Reports, the editorial board of Hypertension and Journal of Hypertension, the meetings committee of the British Pharmacologic Society, the research committee of the Wellcome Trust/Public Health Foundation of India. I chair the educational committee of British Hypertension Society.