His research has been in the study of brain and behavior in healthy people and patients with brain disorders, with a special emphasis on exploiting neuroimaging as experimental probes. As Professor in the Departments of Psychiatry, Radiology & Neurology, and Director of the Brain Behavior Laboratory and the Center for Neuroimaging in Psychiatry, he has developed tools for “deep phenotyping” of brain and behavioral parameters using computerized acquisition tools that can integrate clinical and neurocognitive measures with neuroimaging and genomic data within the framework of large multicenter studies. His work has documented sex differences, aging effects, and abnormalities in regional brain function associated with schizophrenia, affective disorders, stroke, epilepsy, movement disorders and dementia. His work has been supported by grants from the NIMH, NIH, NIA, NINDS, NSF, DOD, NASA, private foundations (Spencer, MacArthur, EJLB, Brain and Behavior Research Foundation) and industry (Pfizer, AstraZeneca, Lilly, Merck).