Her long-term research objective is to design, develop, and evaluate novel technologies that improve the social, cognitive, and emotional wellbeing of people. Having researched games since her first publications in the early 2000s, she has been at the forefront of legitimizing games research in HCI, with more than 200 top-tier publications, including 26 best paper awards and nominations. Together with her trainees, she has made foundational and significant contributions in modeling the emotional experience and personality of players, harnessing game motivation, facilitating social connection through play, combating toxicity within multiplayer games, and harnessing games for the assessment and treatment of mental health.

Regan led Games research in the Canadian GRAND Network, led the first ever Canadian graduate training program on games user research (SWaGUR.ca), and was pivotal in establishing the gaming research community within SIGCHI—particularly in establishing and leading the ACM CHI PLAY conference. She also chaired CHI in 2018 and chaired the CHI Steering Committee from 2019–2022. She was inducted into the Royal Society of Canada’s College of New Scholars, Artists and Scientists in 2014, received the University of Saskatchewan New Researcher Award in 2015, the Canadian Association for Computer Science’s Outstanding Young Canadian Computer Science Researcher Prize in 2016, the prestigious E.W.R. Steacie Fellowship from NSERC in 2018, was inducted into the SIGCHI Academy in 2023, and received the Canadian Human Computer Communications Society’s Achievement Award in 2023.